Publication: Acute phase protein concentrations in retired racing Greyhounds
Authors
Guillermo Couto, C. ; Cerón Madrigal, José Joaquín ; Parra Muñoz, María Dolores ; Martínez-Subiela, Silvi ; Lazbik, M. Cristina
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Publisher
Wiley
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DOI
https://doi.org/10.1111/j.1939-165X.2009.00144.x
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info:eu-repo/semantics/article
Description
© 2009 American Society for Veterinary Clinical Pathology. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. This document is the Accepted version of a Published Work that appeared in final form in Veterinary Clinical Pathology: An International Journal of Laboratory Medicine. To access the final edited and published work see https://doi.org/10.1111/j.1939-165X.2009.00144.x
Abstract
Background: Retired racing Greyhounds are popular as pets. Greyhounds have several differences in physiological values compared with other breeds, including lower serum a- and b-globulin concentrations.
We hypothesized that lower acute phase protein (APP) concentrations could contribute to lower a- and b-globulin concentrations in this breed. Objectives: The purpose of this study was to compare serum concentrations of several APPs in Greyhounds with those of other dog breeds. Methods: We measured the serum concentrations of C-reactive protein (CRP), haptoglobin (Hp), acid-soluble glycoprotein (ASG), ceruloplasmin (CP), and serum amyloid A (SAA) in 15 clinically healthy retired racing Greyhounds and 11 age- and gender-matched healthy nonGreyhound controls using previously validated methods. Results were compared by Student’s t-tests. Results: The concentration of Hp by both colorimetric and immunoturbidimetric methods was significantly lower in Greyhounds than in nonGreyhound dogs (P =.0009 and .019, respectively). The concentration of ASG was also significantly (P =.007) lower in Greyhounds, but CRP and CP concentrations were not significantly different between groups. SAA concentration was below the detection limit of the method in all dogs. Conclusions: The low serum concentrations of Hp and ASG should be taken into consideration when interpreting APP results in Greyhounds. Because both Hp and some ASG migrate in the a-globulin
fraction, these results may explain the low a-globulin concentrations in Greyhounds.
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Citation
Veterinary Clinical Pathology 38(2):219-23
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