Acute phase protein concentrations in retired racing Greyhounds

Guillermo Couto, C.; Cerón Madrigal, José Joaquín; Parra Muñoz, María Dolores; Martínez-Subiela, Silvi; Lazbik, M. Cristina

Publication:
Acute phase protein concentrations in retired racing Greyhounds

dc.contributor.author	Guillermo Couto, C.
dc.contributor.author	Cerón Madrigal, José Joaquín
dc.contributor.author	Parra Muñoz, María Dolores
dc.contributor.author	Martínez-Subiela, Silvi
dc.contributor.author	Lazbik, M. Cristina
dc.contributor.department	Ciencias Sociosanitarias
dc.date.accessioned	2025-01-21T11:45:20Z
dc.date.available	2025-01-21T11:45:20Z
dc.date.issued	2009-06
dc.description	© 2009 American Society for Veterinary Clinical Pathology. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. This document is the Accepted version of a Published Work that appeared in final form in Veterinary Clinical Pathology: An International Journal of Laboratory Medicine. To access the final edited and published work see https://doi.org/10.1111/j.1939-165X.2009.00144.x	es
dc.description.abstract	Background: Retired racing Greyhounds are popular as pets. Greyhounds have several differences in physiological values compared with other breeds, including lower serum a- and b-globulin concentrations. We hypothesized that lower acute phase protein (APP) concentrations could contribute to lower a- and b-globulin concentrations in this breed. Objectives: The purpose of this study was to compare serum concentrations of several APPs in Greyhounds with those of other dog breeds. Methods: We measured the serum concentrations of C-reactive protein (CRP), haptoglobin (Hp), acid-soluble glycoprotein (ASG), ceruloplasmin (CP), and serum amyloid A (SAA) in 15 clinically healthy retired racing Greyhounds and 11 age- and gender-matched healthy nonGreyhound controls using previously validated methods. Results were compared by Student’s t-tests. Results: The concentration of Hp by both colorimetric and immunoturbidimetric methods was significantly lower in Greyhounds than in nonGreyhound dogs (P =.0009 and .019, respectively). The concentration of ASG was also significantly (P =.007) lower in Greyhounds, but CRP and CP concentrations were not significantly different between groups. SAA concentration was below the detection limit of the method in all dogs. Conclusions: The low serum concentrations of Hp and ASG should be taken into consideration when interpreting APP results in Greyhounds. Because both Hp and some ASG migrate in the a-globulin fraction, these results may explain the low a-globulin concentrations in Greyhounds.	es
dc.format	application/pdf	es
dc.format.extent	5	es
dc.identifier.citation	Veterinary Clinical Pathology 38(2):219-23
dc.identifier.doi	https://doi.org/10.1111/j.1939-165X.2009.00144.x
dc.identifier.issn	Print: 0275-6382
dc.identifier.issn	Electronic: 1939-165X
dc.identifier.uri	http://hdl.handle.net/10201/148904
dc.language	eng	es
dc.publisher	Wiley	es
dc.relation	This study was supported in part by the Savannah and Barry French Poodle Memorial Fund.	es
dc.relation.publisherversion	https://onlinelibrary.wiley.com/doi/epdf/10.1111/j.1939-165X.2009.00144.x
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject	Acute phase protein	es
dc.subject	Breed difference	es
dc.subject	Haptoglobin	es
dc.title	Acute phase protein concentrations in retired racing Greyhounds	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es