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p53, latent membrane protein 1, bcl-2, and prognosis in nasopharyngeal carcinoma: a meta-analysis

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dc.contributor.authorYang, Guang Da
dc.contributor.authorWang, Zhi Chao
dc.contributor.authorChen, Qian Ya
dc.contributor.authorZhang, Hai Liang
dc.contributor.authorLin, Xian Gan
dc.contributor.authorHuang, Tie Jun
dc.contributor.authorQian, Chao Nan
dc.contributor.authorHuang, Bi Jun
dc.date.accessioned2022-06-07T12:05:11Z
dc.date.available2022-06-07T12:05:11Z
dc.date.issued2019
dc.description.abstractThe controversy of (p53) in nasopharyngeal carcinoma persists, despite the fact that many studies have been conducted on its correlation with latent membrane protein 1 (LMP1), bcl-2, and prognosis. To better understand this postulated relationship, a metaanalysis was performed based on existing relevant studies. A total of 19 individual studies with a total of 1189 patients were included in the meta-analysis. Overall, the results revealed a significant association of p53-positive status with a poor 5-year survival of nasopharyngeal carcinoma (NPC) patients as the risk difference (RD) was -0.17 (95% CI, -0.31, -0.03; P=0.02, Pheterogeneity=0.01).The overall odds ratio (OR) for LMP1 in the p53 positive group vs. negative group revealed that a significantly elevated risk of positive LMP1 in the former was achieved (OR 5.52 95% CI, 2.66-11.46; P<0.00001, Pheterogeneity=0.78). Similarly, a strong correlation between bcl-2 and p53 was found with an OR 6.85 (95% CI, 2.37-19.74; P=0.0004, Pheterogeneity=0.48). However, there did not appear to be any correlations with clinical parameters such as gender, tumor site, lymph node metastasis, pathological type and TNM stage. In conclusion, p53 expression is related to the survival of nasopharyngeal carcinoma. It can be considered as the auxiliary detection index in treatment and prognosis of nasopharyngeal carcinomaes
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.citationHistology and Histopathology, Vol.34, nÂş2, (2019)
dc.identifier.doiDOI: 10.14670/HH-18-032
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/121007
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de BiologĂ­a Celular e HistologĂ­aes
dc.relationSin financiaciĂłn externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectp53es
dc.subjectLatent membrane protein 1es
dc.subjectLMP1es
dc.subjectBcl-2es
dc.subjectNasopharyngeal carcinomaes
dc.subjectNPCes
dc.subjectPrognostic significancees
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - PatologĂ­a. Medicina clĂ­nica. OncologĂ­aes
dc.titlep53, latent membrane protein 1, bcl-2, and prognosis in nasopharyngeal carcinoma: a meta-analysises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.34, nÂş2 (2019)