Publication: p53, latent membrane protein 1, bcl-2, and prognosis in nasopharyngeal carcinoma: a meta-analysis
Authors
Yang, Guang Da ; Wang, Zhi Chao ; Chen, Qian Ya ; Zhang, Hai Liang ; Lin, Xian Gan ; Huang, Tie Jun ; Qian, Chao Nan ; Huang, Bi Jun
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Publisher
Universidad de Murcia. Departamento de BiologĂa Celular e HistologĂa
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DOI
DOI: 10.14670/HH-18-032
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info:eu-repo/semantics/article
Description
Abstract
The controversy of (p53) in nasopharyngeal
carcinoma persists, despite the fact that many studies
have been conducted on its correlation with latent
membrane protein 1 (LMP1), bcl-2, and prognosis. To
better understand this postulated relationship, a metaanalysis was performed based on existing relevant
studies. A total of 19 individual studies with a total of
1189 patients were included in the meta-analysis.
Overall, the results revealed a significant association of
p53-positive status with a poor 5-year survival of
nasopharyngeal carcinoma (NPC) patients as the risk
difference (RD) was -0.17 (95% CI, -0.31, -0.03;
P=0.02, Pheterogeneity=0.01).The overall odds ratio
(OR) for LMP1 in the p53 positive group vs. negative
group revealed that a significantly elevated risk of
positive LMP1 in the former was achieved (OR 5.52
95% CI, 2.66-11.46; P<0.00001, Pheterogeneity=0.78).
Similarly, a strong correlation between bcl-2 and p53
was found with an OR 6.85 (95% CI, 2.37-19.74;
P=0.0004, Pheterogeneity=0.48). However, there did not
appear to be any correlations with clinical parameters
such as gender, tumor site, lymph node metastasis,
pathological type and TNM stage. In conclusion, p53
expression is related to the survival of nasopharyngeal
carcinoma. It can be considered as the auxiliary
detection index in treatment and prognosis of
nasopharyngeal carcinoma
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Citation
Histology and Histopathology, Vol.34, nÂş2, (2019)
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