Publication: Circadian activity rhythms during the last days of Nothobranchius rachovii’s life: A descriptive model of circadian system breakdown
Authors
Lucas-Sánchez, Alejandro ; Martínez-Nicolás, Antonio ; Madrid, Juan Antonio ; Almaida Pagán, Pedro Francisco ; Mendiola, Pilar ; Costa, Jorge de
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Publisher
Informa Healthcare USA, Inc.
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DOI
https://doi.org/10.3109/07420528.2014.984040
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info:eu-repo/semantics/article
Description
©Informa Healthcare USA, Inc. This document is the Published version of a Published Work that appeared in final form in Chronobiology International: The Journal of Biological and Medical Rhythm Research. To access the final edited and published work see https://doi.org/10.3109/07420528.2014.984040
Abstract
Several studies have been performed to identify age-related changes in the circadian system (CS) but the impairment of the CS and its chronodisruption at the end of an organism life have not been studied in depth. Aging commonly affects the input pathways into the biological clock or restraints their processing, therefore simplifying the system output, the overt rhythms. The purpose of this work was to do a complete characterization of changes that occurs in the CS in the last stage of a vertebrate organism life and to develop tools able to detect in which moment of the last days of life is the animal, using an overt rhythm, the rest-activity rhythm (RAR). For that, a fish species proposed as model for aging studies, Nothobranchius rachovii, has been used. A progressive and sequential CS breakdown has been described for the last 22 d of life of N. rachovii ( 7% of total life), suffering a general RAR impairment mainly reflected by changes in phase regularity, complexity, amplitude and the ability to stay synchronized to the LD cycle.
Also, an equation of days remaining of life, based on the RAR description, has been calculated and proposed as a tool to identify close-to-death individuals which could be subjected to an adequate restoring treatment to enhance the CS function and improve their well-being.
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Citation
Chronobiology International: 1–10, (2014)
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