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Circadian activity rhythms during the last days of Nothobranchius rachovii’s life: A descriptive model of circadian system breakdown

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dc.contributor.authorLucas-Sánchez, Alejandro
dc.contributor.authorMartínez-Nicolás, Antonio
dc.contributor.authorMadrid, Juan Antonio
dc.contributor.authorAlmaida Pagán, Pedro Francisco
dc.contributor.authorMendiola, Pilar
dc.contributor.authorCosta, Jorge de
dc.contributor.departmentFisiología
dc.date.accessioned2024-06-17T11:21:47Z
dc.date.available2024-06-17T11:21:47Z
dc.date.issued2014-11-25
dc.description©Informa Healthcare USA, Inc. This document is the Published version of a Published Work that appeared in final form in Chronobiology International: The Journal of Biological and Medical Rhythm Research. To access the final edited and published work see https://doi.org/10.3109/07420528.2014.984040
dc.description.abstractSeveral studies have been performed to identify age-related changes in the circadian system (CS) but the impairment of the CS and its chronodisruption at the end of an organism life have not been studied in depth. Aging commonly affects the input pathways into the biological clock or restraints their processing, therefore simplifying the system output, the overt rhythms. The purpose of this work was to do a complete characterization of changes that occurs in the CS in the last stage of a vertebrate organism life and to develop tools able to detect in which moment of the last days of life is the animal, using an overt rhythm, the rest-activity rhythm (RAR). For that, a fish species proposed as model for aging studies, Nothobranchius rachovii, has been used. A progressive and sequential CS breakdown has been described for the last 22 d of life of N. rachovii ( 7% of total life), suffering a general RAR impairment mainly reflected by changes in phase regularity, complexity, amplitude and the ability to stay synchronized to the LD cycle. Also, an equation of days remaining of life, based on the RAR description, has been calculated and proposed as a tool to identify close-to-death individuals which could be subjected to an adequate restoring treatment to enhance the CS function and improve their well-being.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.citationChronobiology International: 1–10, (2014)
dc.identifier.doihttps://doi.org/10.3109/07420528.2014.984040
dc.identifier.issnPrint: 0742-0528
dc.identifier.issnElectronic: 1525-6073
dc.identifier.urihttp://hdl.handle.net/10201/142358
dc.languageenges
dc.publisherInforma Healthcare USA, Inc.es
dc.relationThis project was funded by the Seneca Foundation (12005/PI/09), Instituto de Salud Carlos III (RETICEF, RD12/0043/0011) and the Spanish Ministry of Science and Education (BFU2010-21945-C02-01), including FEDER co-funding. Pedro Francisco Almaida Pagan was funded by a Marie Curie Intra-European Fellowship within the 7th Community Framework Program (PIEF-GA-2011-297964, OLDMITO).es
dc.relation.publisherversionhttps://www.tandfonline.com/doi/full/10.3109/07420528.2014.984040es
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectAging modeles
dc.subjectCircadian system
dc.subjectCircadian system breakdown
dc.subjectDeath
dc.subjectLocomotor activity
dc.subjectNothobranchius
dc.titleCircadian activity rhythms during the last days of Nothobranchius rachovii’s life: A descriptive model of circadian system breakdownes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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