Publication: Serum biomarkers of oxidative stress in dogs with idiopathic inflammatory bowel disease
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Date
2017-03
Authors
Peres Rubio, Camila ; Martínez-Subiela, S. ; Tvarijonaviciute, Asta ; Cerón, J.J. ; Allenspach, K. ; Hernández Ruiz, Josefa
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Publisher
Elsevier
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DOI
https://doi.org/10.1016/j.tvjl.2017.02.003
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info:eu-repo/semantics/article
Description
© 2017 Elsevier Ltd.
This document is the published version of a published work that appeared in final form in Veterinary Journal.
To access the final edited and published work see:
https://doi.org/10.1016/j.tvjl.2017.02.003
Abstract
The objective of this work was to study and compare a panel of various serum biomarkers evaluating
both the antioxidant response and oxidative damage in dogs with idiopathic inflammatory bowel disease
(IBD). Eighteen dogs with IBD and 20 healthy dogs were enrolled in the study. Trolox equivalent antioxidant
capacity (TEAC), cupric reducing antioxidant capacity (CUPRAC), ferric reducing ability of the plasma
(FRAP), total thiol concentrations, and paraoxonase 1 (PON1) activity were evaluated in serum to determine
antioxidant response. To evaluate oxidative status, ferrous oxidation-xylenol orange (FOX),
thiobarbituric acid reactive substances (TBARS) and reactive oxygen species production (ROS) concentrations
in serum were determined.
Mean concentrations of all antioxidant biomarkers analyzed, with exception of FRAP, were significantly
lower (P < 0.0001) in the sera of dogs with IBD than in healthy dogs. The oxidant markers studied
were significantly higher (P < 0.0001) in sera of dogs with IBD than in healthy dogs. These findings support
the hypothesis that oxidative stress could play an important role in the pathogenesis of canine IBD.
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Citation
Veterinary Journal, Volume 221, March 2017, Pages 56-61
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