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Serum biomarkers of oxidative stress in dogs with idiopathic inflammatory bowel disease

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dc.contributor.authorPeres Rubio, Camila
dc.contributor.authorMartínez-Subiela, S.
dc.contributor.authorTvarijonaviciute, Asta
dc.contributor.authorCerón, J.J.
dc.contributor.authorAllenspach, K.
dc.contributor.authorHernández Ruiz, Josefa
dc.contributor.departmentMedicina y Cirugía Animal
dc.date.accessioned2025-02-01T22:15:11Z
dc.date.available2025-02-01T22:15:11Z
dc.date.issued2017-03
dc.description© 2017 Elsevier Ltd. This document is the published version of a published work that appeared in final form in Veterinary Journal. To access the final edited and published work see: https://doi.org/10.1016/j.tvjl.2017.02.003
dc.description.abstractThe objective of this work was to study and compare a panel of various serum biomarkers evaluating both the antioxidant response and oxidative damage in dogs with idiopathic inflammatory bowel disease (IBD). Eighteen dogs with IBD and 20 healthy dogs were enrolled in the study. Trolox equivalent antioxidant capacity (TEAC), cupric reducing antioxidant capacity (CUPRAC), ferric reducing ability of the plasma (FRAP), total thiol concentrations, and paraoxonase 1 (PON1) activity were evaluated in serum to determine antioxidant response. To evaluate oxidative status, ferrous oxidation-xylenol orange (FOX), thiobarbituric acid reactive substances (TBARS) and reactive oxygen species production (ROS) concentrations in serum were determined. Mean concentrations of all antioxidant biomarkers analyzed, with exception of FRAP, were significantly lower (P < 0.0001) in the sera of dogs with IBD than in healthy dogs. The oxidant markers studied were significantly higher (P < 0.0001) in sera of dogs with IBD than in healthy dogs. These findings support the hypothesis that oxidative stress could play an important role in the pathogenesis of canine IBD.
dc.formatapplication/pdfes
dc.format.extent6
dc.identifier.citationVeterinary Journal, Volume 221, March 2017, Pages 56-61
dc.identifier.doihttps://doi.org/10.1016/j.tvjl.2017.02.003
dc.identifier.issnElectronic.: 1532-2971
dc.identifier.issnPrint.: 1090-0233
dc.identifier.urihttp://hdl.handle.net/10201/149927
dc.languageenges
dc.publisherElsevier
dc.relation• Seneca Foundation of Murcia Region • Ministerio de Economía y Competitividad • Conselho Nacional de Desenvolvimento Científico e Tecnológicoes
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1090023317300448?via%3Dihub
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectAntioxidant
dc.subjectCupric
dc.subjectPON1
dc.subjectReactive oxygen species
dc.subjectThiol
dc.titleSerum biomarkers of oxidative stress in dogs with idiopathic inflammatory bowel diseasees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublication04cc5ea0-ac13-435b-81f3-ea78cdd30554
relation.isAuthorOfPublication.latestForDiscovery04cc5ea0-ac13-435b-81f3-ea78cdd30554
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