Publication: Metabolomics study of the formation of genotoxic molecules based on the fecal volatile metabolites profile using an in vivo animal model
Authors
Giménez Campillo, Claudia ; Campillo Seva, Natalia ; Arroyo Manzanares, Natalia ; Torre-Minguela, Carlos de ; Viñas López-Pelegrin, Pilar ; Martínez Cáceres, Carlos Manuel
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Publisher
Elsevier
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DOI
https://doi.org/10.1016/j.microc.2024.110132
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info:eu-repo/semantics/article
Description
Abstract
Epidemiological studies have shown that haem iron from processed meat is a key element involved in the colon carcinogenesis. The haem iron induces lipid peroxidation in the colon lumen during digestion, enabling the formation of cytotoxic molecules derived from these reactions. The cytotoxic molecules generated are highly dependent on dietary factors such as lipid sources, calcium levels or the presence of antioxidants during digestion. Here, we investigated whether nitrite substitution by polyphenols as a food additive could modulate the in vivo luminal lipid peroxidation in the colon and consequently, reduce the formation of mucin-depleted foci in a chemical-induced colon cancer rat model. The addition of polyphenols to the cooked ham diet reduces the lipid peroxidation in the rats. A reduction in cytotoxic aldehydes in fecal water from animals fed with polyphenols as well as a decrease in the formation of mucin-depleted foci is observed. The antioxidant capacity derived from polyphenols modifies the luminal environment of the colon, allowing the identification of a specific molecular signature derived from the analysis of fecal volatile organic compounds. In this molecular signature is included the reduction in the abundance of (2E,4E)-2,4-hexadienal, a carcinogenic aldehyde derived from lipid peroxidation.
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Citation
Microchemical Journal, 2024, Vol. 199 : 110132
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