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Metabolomics study of the formation of genotoxic molecules based on the fecal volatile metabolites profile using an in vivo animal model

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dc.contributor.authorGiménez Campillo, Claudia
dc.contributor.authorCampillo Seva, Natalia
dc.contributor.authorArroyo Manzanares, Natalia
dc.contributor.authorTorre-Minguela, Carlos de
dc.contributor.authorViñas López-Pelegrin, Pilar
dc.contributor.authorMartínez Cáceres, Carlos Manuel
dc.contributor.departmentQuímica Analítica
dc.date.accessioned2025-10-16T06:28:44Z
dc.date.available2025-10-16T06:28:44Z
dc.date.copyright© 2024 The Author(s)
dc.date.issued2024-02-09
dc.description.abstractEpidemiological studies have shown that haem iron from processed meat is a key element involved in the colon carcinogenesis. The haem iron induces lipid peroxidation in the colon lumen during digestion, enabling the formation of cytotoxic molecules derived from these reactions. The cytotoxic molecules generated are highly dependent on dietary factors such as lipid sources, calcium levels or the presence of antioxidants during digestion. Here, we investigated whether nitrite substitution by polyphenols as a food additive could modulate the in vivo luminal lipid peroxidation in the colon and consequently, reduce the formation of mucin-depleted foci in a chemical-induced colon cancer rat model. The addition of polyphenols to the cooked ham diet reduces the lipid peroxidation in the rats. A reduction in cytotoxic aldehydes in fecal water from animals fed with polyphenols as well as a decrease in the formation of mucin-depleted foci is observed. The antioxidant capacity derived from polyphenols modifies the luminal environment of the colon, allowing the identification of a specific molecular signature derived from the analysis of fecal volatile organic compounds. In this molecular signature is included the reduction in the abundance of (2E,4E)-2,4-hexadienal, a carcinogenic aldehyde derived from lipid peroxidation.
dc.formatapplication/pdf
dc.identifier.citationMicrochemical Journal, 2024, Vol. 199 : 110132
dc.identifier.doihttps://doi.org/10.1016/j.microc.2024.110132
dc.identifier.eissn1095-9149
dc.identifier.issn0026-265X
dc.identifier.urihttp://hdl.handle.net/10201/166729
dc.languageeng
dc.publisherElsevier
dc.relationComunidad Autónoma de la Región de Murcia (CARM, Fundación Séneca, Project (21671/PDC/21)
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0026265X24002443º
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectVolatile Organic Compounds
dc.subjectPolyphenols
dc.subjectLipid peroxidation
dc.subjectRat model
dc.subjectMetabolomics
dc.subjectGas chromatography Mass Spectrometry
dc.subject.odsObjetivo 2: Hambre y seguridad alimentaria
dc.titleMetabolomics study of the formation of genotoxic molecules based on the fecal volatile metabolites profile using an in vivo animal model
dc.typeinfo:eu-repo/semantics/article
dspace.entity.typePublicationes
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