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Different effects of neurotensin and neuromedin-N on the proliferative activity of rat adrenal cortex

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dc.contributor.authorMarkowska, A.es
dc.contributor.authorNussdorfer, G.G.es
dc.contributor.authorMalendowicz, L.K.
dc.date.accessioned2011-02-01T09:18:26Z
dc.date.available2011-02-01T09:18:26Z
dc.date.issued1994
dc.description.abstractEvidence indicates that neurotensin (NT) and neuromedin-N (NMN) exerts an adrenocorticotropic effect in the rat. The present study aimed to investigate whether these neuropeptides are able to stimulate the proliferation of rat adrenocortical cells in vivo and to compare their mode of action. Adrenocortical proliferative activity was assessed by the metaphasearrest technique and metaphases were counted per medulla-containing adrenal section. A bolus administration of NT (3 pglrat) resulted in a significant increase in the number of metaphases in both zona fasciculata and the entire cortex, an effect observed 48 h after the in.jection. The administration of NMN (3 yglrat) induced a notable rise in the number of metaphases in the zona fasciculata and the entire cortex within 12 h, followed by a subsequent drop after 24 h and a return to normal values at 48 h. These findings indicate that NT and NMN enhance rat adrenal growth in vivo acting via different mediators.es
dc.formatapplication/pdfes
dc.format.extent4es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/18526
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectNeurotensines
dc.subjectNeuromedin Nes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleDifferent effects of neurotensin and neuromedin-N on the proliferative activity of rat adrenal cortexes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol. 9, nº 3 (1994)