Publication: Different effects of neurotensin and neuromedin-N on the proliferative activity of rat adrenal cortex
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Date
1994
Authors
Markowska, A. ; Nussdorfer, G.G. ; Malendowicz, L.K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Evidence indicates that neurotensin (NT) and
neuromedin-N (NMN) exerts an adrenocorticotropic
effect in the rat. The present study aimed to investigate
whether these neuropeptides are able to stimulate the
proliferation of rat adrenocortical cells in vivo and
to compare their mode of action. Adrenocortical
proliferative activity was assessed by the metaphasearrest
technique and metaphases were counted
per medulla-containing adrenal section. A bolus
administration of NT (3 pglrat) resulted in a significant
increase in the number of metaphases in both zona
fasciculata and the entire cortex, an effect observed 48 h
after the in.jection. The administration of NMN (3 yglrat)
induced a notable rise in the number of metaphases in
the zona fasciculata and the entire cortex within 12 h,
followed by a subsequent drop after 24 h and a return to
normal values at 48 h. These findings indicate that NT
and NMN enhance rat adrenal growth in vivo acting via
different mediators.
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