Publication: The expression of Smad signaling pathway in myocardium and potential therapeutic effects
Authors
Duan, Yongjian ; Zhu, Wei ; Liu, Min ; Ashraf, Muhammad ; Xu, Meifeng
item.page.secondaryauthor
item.page.director
Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
publication.page.editor
publication.page.department
DOI
DOI:10.14670/ HH-11-845
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Myocardial infarction (MI) is a lifethreatening disease. The expression of Smad proteins in
the ischemic myocardium changes significantly
following myocardial infarction, suggesting a close
relationship between Smad proteins and heart
remodeling. Moreover, it is known that the expression of
Smads is regulated by transforming growth factor-β
(TGF-β) and bone morphogenetic proteins (BMP).
Based on these findings, regulating the expression of
Smad proteins by targeting TGF-β and BMP in the
ischemic myocardium may be considered to be a
possible therapeutic strategy for the treatment of
myocardial infarction
publication.page.subject
Citation
Histology and Histopathology, Vol.32, nº7, (2017)
item.page.embargo
Ir a Estadísticas
Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/