Browsing by Subject "Smad"

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    The expression of Smad signaling pathway in myocardium and potential therapeutic effects
    (Universidad de Murcia. Departamento de Biología Celular e Histología, 2017) Duan, Yongjian; Zhu, Wei; Liu, Min; Ashraf, Muhammad; Xu, Meifeng
    Myocardial infarction (MI) is a lifethreatening disease. The expression of Smad proteins in the ischemic myocardium changes significantly following myocardial infarction, suggesting a close relationship between Smad proteins and heart remodeling. Moreover, it is known that the expression of Smads is regulated by transforming growth factor-β (TGF-β) and bone morphogenetic proteins (BMP). Based on these findings, regulating the expression of Smad proteins by targeting TGF-β and BMP in the ischemic myocardium may be considered to be a possible therapeutic strategy for the treatment of myocardial infarction