Publication: Comparison of the dysadherin and E-cadherin expression in primary lung cancer and metastatic sites
Authors
Mitselou, Antigony ; Batistatou, Anna ; Nakanishi, Yukihiro ; Hirohashi, Setsuo ; Vougiouklakis, Theodoros ; Charalabopoulos, Konstantinos
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Dysadherin, a cancer associated cell
membrane glycoprotein, has been reported to
downregulate E-cadherin. Aberrant expression of Ecadherin
has been associated with the development of
metastases in patients with cancer. Even though the
expression of dysadherin and E-cadherin has been
studied in primary non-small cell lung carcinoma, little
is known about its expression at the distant metastases
sites. We investigate by immunohistochemistry the
relationship between E-cadherin and dysadherin in 111
cases of primary lung carcinomas (53 squamous cell
carcinomas, 21 adenocarcinomas, 13 large cell
carcinomas, and 24 small cell carcinomas), and their
distant metastases. The intensity, the expression pattern
and the percentage of neoplastic cell staining were
recorded and the results were correlated with
clinicopathological findings of the subjects. Dysadherin
immunostain was expressed in 61 (54.95%) of the cases,
and increased dysadherin expression was significantly
correlated with tumour size (p=0.003), distant metastases
(p=0.0034), and metastasis size (p=0.0008). Reduced Ecadherin
expression was noted in 46 (41.45%) of the
cases, and was correlated with high-grade tumour
(p=0.02), infiltrative growth pattern (p=0.042), and
advanced stage (p=0.032). Although the correlation
between the expression of dysadherin and E-cadherin
was not significant, a group of patients showed reduced
E-cadherin expression with dysadherin overexpression.
In lung carcinomas dysadherin expression seems to
reflect tumour aggressiveness and may be considered a
positive marker of poor prognosis when considered
alone or/and in combination with down-regulation of Ecadherin.
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