Publication: Ovariectomy-induced changes in the adrenal cortex of spontaneously hypertensive rats
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Date
1991
Authors
Stachowiak, A. ; Nussdorfer, G.G. ; Malendowicz, L.K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Many lines of evidence indicate that
adrenocortical steroid hormones are involved in the
development and maintenance of hypertension in
spontaneously hypertensive rats (SHR). Twenty-eight
days after ovariectomy a notable decrease in the sistolic
blood pressure (BP) was found in SHR, along with a
marked atrophy of their adrenal cortices. The hypothesis
is advanced that the ovariectomy-induced lowering in
BP in SHR may be, at least partly, mediated by the
suppression of the adrenal secretory activity, due to the
lack of circulating estrogens, which are well known to
stimulate hypophyseal ACTH release.
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Citation
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