Publication: Clinico-pathological correlations in meningiomas, a DNA and immunohistochemical study
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Date
1993
Authors
Cruz-Sánchez, F. F. ; Miquel, R. ; Rossi, M.L. ; Figols, J. ; Palacín, A. ; Cardesa, Antonio
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
We have studied 41 meningiomas classified
histologically as benjgn, atypical or anaplastic. There
were 26 females and 15 males and the mean age was 53
years. 36 tumours were supratentorial, 4 infratentorial
and one spinal. Flow cytometry was performed on
paraffin-embedded tissue using a selective staining
technique for DNA. The ploidy index of DNA and
percentage of cells in the S and G2/M phases were
calculated. Results were correlated with clinical,
histological and immunohistological data. 16/41 tumours .
were found to be diploid, 17/41 aneuploid and 8/41
could not be analysed. Significant correlations were
found between aneuploid tumours and some qualitative
features such as recurrence, pleomorphism, high cellular
density, mitotic activity and brain and soft tissue
infiltration. A high proliferative index appeared to be
associated with clinical aggressiveness. No particular
correlation between the expression of cytokeratin and
epithelial membrane antigen markers and flow
cytometry was found. Our results suggest that DNA flow
cytometry in meningiomas may be of value in predicting
the behaviour of these neoplasms and confirm that
epithelial pattern in meningiomas is not linked to
increased anaplasia or poor prognosis.
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