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Clinico-pathological correlations in meningiomas, a DNA and immunohistochemical study

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dc.contributor.authorCruz-Sánchez, F. F.
dc.contributor.authorMiquel, R.
dc.contributor.authorRossi, M.L.
dc.contributor.authorFigols, J.
dc.contributor.authorPalacín, A.
dc.contributor.authorCardesa, Antonio
dc.date.accessioned2017-06-06T12:39:07Z
dc.date.available2017-06-06T12:39:07Z
dc.date.issued1993
dc.description.abstractWe have studied 41 meningiomas classified histologically as benjgn, atypical or anaplastic. There were 26 females and 15 males and the mean age was 53 years. 36 tumours were supratentorial, 4 infratentorial and one spinal. Flow cytometry was performed on paraffin-embedded tissue using a selective staining technique for DNA. The ploidy index of DNA and percentage of cells in the S and G2/M phases were calculated. Results were correlated with clinical, histological and immunohistological data. 16/41 tumours . were found to be diploid, 17/41 aneuploid and 8/41 could not be analysed. Significant correlations were found between aneuploid tumours and some qualitative features such as recurrence, pleomorphism, high cellular density, mitotic activity and brain and soft tissue infiltration. A high proliferative index appeared to be associated with clinical aggressiveness. No particular correlation between the expression of cytokeratin and epithelial membrane antigen markers and flow cytometry was found. Our results suggest that DNA flow cytometry in meningiomas may be of value in predicting the behaviour of these neoplasms and confirm that epithelial pattern in meningiomas is not linked to increased anaplasia or poor prognosis.
dc.formatapplication/pdfes
dc.format.extent8
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/53197
dc.languageenges
dc.publisherMurcia : F. Hernández
dc.relation.ispartofHistology and histopathology
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectMeningioma
dc.subjectDNA
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina
dc.titleClinico-pathological correlations in meningiomas, a DNA and immunohistochemical studyes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol. 8, nº 1 (1993)