Publication: Optimal mesenchymal stem cell delivery routes to enhance neurogenesis for the treatment of Alzheimer's disease
Authors
Park, Sang Eon ; Lee, Na Kyung ; Na, Duk L. ; Chang, Jong Wook
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
DOI: 10.14670/HH-11-950
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info:eu-repo/semantics/article
Description
Abstract
Alzheimer’s disease (AD) is a common cause
of dementia. Alzheimer’s disease (AD) is characterized
by progressive loss of memory in addition to cortical
atrophy. Despite decades of research and therapeutic
trials in AD, an effective treatment is yet to be
developed. Mesenchymal stem cells (MSCs) have
emerged as promising tools for the treatment of AD, and
clinical trials have been completed or are in progress.
MSCs secrete various cytotropic factors that may exert
beneficial effects in AD. The route of administration is
an important factor to enhance MSC based treatment
effects for AD. Among various routes, the
intracerebroventricular route may possess several
advantages such as the activation of neurogenesis,
compared to other routes for AD treatments. In this
review, we will focus on recent pre-clinical and clinical
advances in MSC-based treatment of AD, specifically in
relation to enhancement of endogenous neurogenesis.
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Citation
Histology and Histopathology, Vol.33, nº6, (2018)
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