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Optimal mesenchymal stem cell delivery routes to enhance neurogenesis for the treatment of Alzheimer's disease

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dc.contributor.authorPark, Sang Eon
dc.contributor.authorLee, Na Kyung
dc.contributor.authorNa, Duk L.
dc.contributor.authorChang, Jong Wook
dc.date.accessioned2022-04-08T10:31:31Z
dc.date.available2022-04-08T10:31:31Z
dc.date.issued2018
dc.description.abstractAlzheimer’s disease (AD) is a common cause of dementia. Alzheimer’s disease (AD) is characterized by progressive loss of memory in addition to cortical atrophy. Despite decades of research and therapeutic trials in AD, an effective treatment is yet to be developed. Mesenchymal stem cells (MSCs) have emerged as promising tools for the treatment of AD, and clinical trials have been completed or are in progress. MSCs secrete various cytotropic factors that may exert beneficial effects in AD. The route of administration is an important factor to enhance MSC based treatment effects for AD. Among various routes, the intracerebroventricular route may possess several advantages such as the activation of neurogenesis, compared to other routes for AD treatments. In this review, we will focus on recent pre-clinical and clinical advances in MSC-based treatment of AD, specifically in relation to enhancement of endogenous neurogenesis.es
dc.formatapplication/pdfes
dc.format.extent9es
dc.identifier.citationHistology and Histopathology, Vol.33, nº6, (2018)
dc.identifier.doiDOI: 10.14670/HH-11-950
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/118924
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de Biología Celular e Histología
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMSCses
dc.subjectAlzheimer's diseasees
dc.subjectDelivery routees
dc.subjectNeurogenesises
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleOptimal mesenchymal stem cell delivery routes to enhance neurogenesis for the treatment of Alzheimer's diseasees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.33, nº6 (2018)