Publication: Nuclear morphometry lacks prognostic value in squamous cell carcinoma of the oesophagus
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Date
1993
Authors
Rodriguez Sanjuan, J.C. ; Val Bernal, F. ; Blanco Garcia, C. ; Garcia-Castrillo Riesgo, L.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
In order to determine the possible influence
in oesophageal squamous cell carcinoma of nuclear
measurements on patients' postoperative survival and on
various histological tumour features, we performed a
nuclear morphometry study on 53 patients (50 males, 3
females) with a mean age of 57.4 years (37-79).
A statistical correlation was revealed between area,
perimeter and diameter and the analysis was, therefore,
performed only in terms of nuclear area.
No influence of nuclear area on postoperative
survival was observed. Nor was a relationship fourld
between rnean nuclear area and either involvement of
the oesophageal wall or degree of histological
differentiation. The tumours showing expansive growth
had a larger mean nuclear area than those of the
infiltrative growth type, although differences did not
reach statistical significance.
The nuclear area standard deviation (reflecting
anisocytosis of the tumour) showed no correlation with
sllrvivill.
In conclusion. our data do not support that
measurement of nuclear parameters by static methods is
of any prognostic value in surgically-treated squamous
cell carcinoma of the oesophagus.
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