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A genetic model for undifferentiated cell tumor formation: similar tumors formed by different cell lines transformed by the EIA oncogene

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dc.contributor.authorRamón y Cajal, S.es
dc.contributor.authorSánchez-Prieto, R.es
dc.contributor.authorAnaya, A.
dc.date.accessioned2011-02-22T10:31:22Z
dc.date.available2011-02-22T10:31:22Z
dc.date.issued1995
dc.description.abstractThe activation of oncogenes and the mutation/deletion of supressor genes may be involved in tumor heterogeneity. In an attempt to study tumor heterogeneity, we transformed cell lines from epithelial (PAM 212), mesenchymal (NIH-3T3), or melanocytic origin (L-BIOBR) with the wild type Ela oncogene. To make the cell lines tumorigenic, cells were infected with Harvey sarcoma virus carrying the v-H-ras oncogene. The transformed cells were injected into nude mice and the tumors studied by optical and electron microscopy. The tumors formed by v-H-ras-transformed cells consisted of epitheliod melanomas, spindle cells sarcomas and poorly-differentiated carcinomas, depending on the cell of origin. In contrast, the tumors obtained from cells also carrying the Ela oncogene showed a predominant small and undifferentiated cell pattem regardless of the cell of origin. We conclude that the Ela oncogene products induce a negative control of differentiation, independent of the cell type, and that tumors formed by cells carrying the Ela oncogene display an undifferentiated cell pattem.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/18790
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectHeterogeneityes
dc.subjectUndifferentiated tumorses
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleA genetic model for undifferentiated cell tumor formation: similar tumors formed by different cell lines transformed by the EIA oncogenees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.10, nº 4 (1995)