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Origin and differentiation of gut endocrine cells

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dc.contributor.authorRawdon, B.B.es
dc.contributor.authorAndrew, A.es
dc.date.accessioned2011-02-01T09:16:54Z
dc.date.available2011-02-01T09:16:54Z
dc.date.issued1993
dc.description.abstractThe epithelium of the digestive tract contains endocrine cells which produce serotonin and an array of regulatory peptides. It is now irrefutably established that gut endocrine cells are not of neural crest nor even of neurectodermal origin. Furthermore, the proposal that they might originate from neuroendocrine-programmed epiblast has been retused by recent evidence that they share the endodermal stem cell pool with the other epithelia1 cells of the gut. Based on the available evidence, a working hypothesis for the differentiation of gut endocrine cells has been developed. It is proposed that initially the developing gut acquires an underlying tendency to differentiate into intestine: the endoderm has the potential to form a wide range of endocrine cell types. A little later, some influence operative over the length of the presumptive gut imposes a regionally specific pattern on the tract. This process concerns morphogenesis and pre-selection of the range and proportions of the endocrine cell types. Thereafter, the mesenchyme feeds to the endoderm confirmatory signals reinforcing this pre-selected regional pattern of endocrine cells. Once the different endocrine cell types have started to differentiate, their maturation is effected by circulating factors which include glucocorticoid hormone: this process is mediated by the mesenchyme. Other factors concerned at various stages of gut endocrine cell differentiation could be other hormones, growth factors and or components of extracellular matrix: such factors are still untested in this context.es
dc.formatapplication/pdfes
dc.format.extent14es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/18427
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectCytodifferentiationes
dc.subjectGut endocrine cellses
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleOrigin and differentiation of gut endocrine cellses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol. 8, nº 3 (1993)