Publication: Origin and differentiation of gut endocrine cells
Authors
Rawdon, B.B. ; Andrew, A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The epithelium of the digestive tract contains
endocrine cells which produce serotonin and an array of
regulatory peptides. It is now irrefutably established that
gut endocrine cells are not of neural crest nor even of
neurectodermal origin. Furthermore, the proposal that
they might originate from neuroendocrine-programmed
epiblast has been retused by recent evidence that they
share the endodermal stem cell pool with the other
epithelia1 cells of the gut.
Based on the available evidence, a working
hypothesis for the differentiation of gut endocrine cells
has been developed. It is proposed that initially the
developing gut acquires an underlying tendency to
differentiate into intestine: the endoderm has the
potential to form a wide range of endocrine cell types. A
little later, some influence operative over the length of
the presumptive gut imposes a regionally specific pattern
on the tract. This process concerns morphogenesis and
pre-selection of the range and proportions of the
endocrine cell types. Thereafter, the mesenchyme feeds
to the endoderm confirmatory signals reinforcing this
pre-selected regional pattern of endocrine cells. Once the
different endocrine cell types have started to
differentiate, their maturation is effected by circulating
factors which include glucocorticoid hormone: this
process is mediated by the mesenchyme. Other factors
concerned at various stages of gut endocrine cell
differentiation could be other hormones, growth factors
and or components of extracellular matrix: such factors
are still untested in this context.
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