Publication: Hypothalamocerebellar and cerebellohypothalamic projections - circuits for regulating nonsomatic cerebellar activity.
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Date
1994
Authors
Dietrichs, E. ; Haines, D.E. ; Roste, G. K. ; Roste, L. S.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Cerebellar involvement in visceral and
affective responses is known from physiological and
behavioral studies, but the pathways involved in these
responses have remained enigmatic. Over the last ten
years neuroanatomical studies have shown that the
cerebellum and hypothalamus are interconnected by
direct hypothalamocerebellar and cerebellohypothalamic
projections and by a multitude of indirect pathways. The
hypothalamocerebellar projection terminates in the
cerebellar nuclei and in all layers of the cerebellar cortex
as multilayered fibres. This projection is, at least in part,
histaminergic. New immunocytochemical experiments
indicate that small numbers of hypothalamocerebellar
neurones may contain GABA- or glycine-like immunoreactivity.
GABA may function as a transmitter in
hypothalamocerebellar fibres, probably in conjunction
with histamine, but it is not clear whether glycine may
also function as a transmitter or only serve metabolic
functions.
The bidirectional pathways between the cerebellum
and hypothalamus may be part of the circuits through
which the cerebellum participates in the modulation of a
variety of nonsomatic events. In addition, new
observations on patients with well localized cerebellar
lesions reveal simultaneous somatic and visceral
dysfunction. Recent research on direct hypothalamocerebellar
pathways and on other connections
between hypothalamus and cerebellum is reviewed. It
is hypothesized that the cerebellum may act as a
general modulator and coordinator of a wide range
of central nervous activities, somatic as well as nonsomatic.
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