Publication: Yolkin tempers inflammatory mediator release and liver pathology in experimental endotoxemia in mice
Authors
Jolanta Artym ; Maja Kocięba ; Ewa Zaczyńska ; Kaleta-Kuratewicz ; Jan P. Madej ; Piotr Kuropka ; Aleksandra Zambrowicz ; Łukasz Bobak ; Michał Zimecki
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Publisher
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Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-25-031
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info:eu-repo/semantics/article
Description
Abstract
Yolkin is an egg yolk-derived protein with
immunoregulatory properties. In this work, yolkin was
evaluated as a protective agent in endotoxemic BALB/c
mice. The mice were pretreated with yolkin either orally
in drinking water or intraperitoneally (i.p.) before i.p.
injection of E. coli lipopolysaccharide (LPS). Circulating
blood leukocyte number, blood cell composition, serum
levels of tumor necrosis factor alpha (TNF-α),
interleukin 6 (IL-6), and haptoglobin, as well as
histological changes in the spleen and the liver, were
examined. Yolkin differentially regulated the values of
these parameters, depending on the administration
protocol; however, the serum levels of TNF-α and IL-6
were generally decreased, and the level of haptoglobin,
an acute-phase protein, was elevated. The pretreatment
of mice with yolkin led to improved histological
architecture in the investigated organs of endotoxemic
mice, particularly in the liver, where yolkin diminished
an increased level of vascular permeability and reversed
a decreased number of Kupffer cells. These changes
were independent of the route of yolkin administration.
In conclusion, yolkin proved effective in the
amelioration of pathogenic consequences of LPS
administration and may be considered a potential
protective measure for patients at risk of endotoxemia.
Histol Histopathol
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