Publication:
A review of neoplasms with MITF/MiT family translocations

Thumbnail Image
Files
Wei-37-311-321-2022.pdf(8 MB)
Date
2022
relationships.isAuthorOfPublication
relationships.isSecondaryAuthorOf
relationships.isDirectorOf
Authors
Wei, Shuanzeng ; Testa, Joseph R. ; Argani, Pedram
item.page.secondaryauthor
item.page.director
Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
publication.page.editor
publication.page.department
DOI
https://doi.org/10.14670/HH-18-426
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Microphthalmia-associated transcription factor (MITF/MiT) family is a group of basic helix-loophelix leucine zipper (bHLH-LZ) transcription factors including TFE3 (TFEA), TFEB, TFEC and MITF. The first described neoplasms involving MITF family translocation were renal cell carcinomas with chromosome translocations involving ASPLTFE3/t(X;17)(p11.23;q25) or MALAT1-TFEB/t(6;11) (p21.1;q12), and now it is known as MiT family translocation RCC in 2016 WHO classification. Translocations involving MITF family genes also are found in other tumor types, such as perivascular epithelioid cell neoplasm (PEComa), alveolar soft part sarcoma (ASPS), epithelioid hemangioendothelioma, ossifying fibromyxoid tumor (OFMT), and clear cell tumor with melanocytic differentiation and ACTINMITF translocation. In this review, we summarize the features of different types of neoplasms with MITF family translocations.
publication.page.subject
MITF , MiT , TFE3 , TFEB , MITF , Translocation , Fusion genes , Neoplasm , Carcinoma , Sarcoma
Citation
Histology and Histopathology Vol. 37, nº4 (2022)
URI
http://hdl.handle.net/10201/128430
item.page.embargo
Collections
Histology and histopathology Vol.37, nº4 (2022)
Ir a Estadísticas