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Effects of omeprazole on the number of immunoreactive gastrin- and somatostatin-cells in the rat gastric mucosa

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Effects of omeprazole on the number of immunoreactive gastrin and somatostatincells in the rat gastric mucosa.pdf(700.15 KB)
Date
1992
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Authors
Pawlikowski, M. ; Karbownik, M. ; Lewinski, A. ; Pisarek, Hanna ; Wajs, E. ; Szkudlinski, M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The effects of omeprazole - an inhibitor of gastric acid secretion - on gastrin (G)- and somatostatin (D)-cell density in the gastric antral mucosa epithelium in rats were examined, following a 5-day treatment. It was found that omeprazole increased the density of G-cells, whereas it decreased the density of D-cells. That effect was probably independent of hypergastrinaemia, since it could not be blocked by a simultaneous treatment with proglumide - a gastrin receptor blocker. It is concluded that the observed phenomenon is a direct result of a lower gastric acidity, as a consequence of omeprazole treatment.
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Gastric antral mucosa , Omeprazole
Citation
URI
http://hdl.handle.net/10201/18295
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Histology and histopathology Vol. 7, nº 2 (1992)
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