Browsing by Subject "Omeprazole"
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- PublicationOpen AccessEffects of omeprazole on the number of immunoreactive gastrin- and somatostatin-cells in the rat gastric mucosa(Murcia : F. Hernández, 1992) Pawlikowski, M.; Karbownik, M.; Lewinski, A.; Pisarek, Hanna; Wajs, E.; Szkudlinski, M.The effects of omeprazole - an inhibitor of gastric acid secretion - on gastrin (G)- and somatostatin (D)-cell density in the gastric antral mucosa epithelium in rats were examined, following a 5-day treatment. It was found that omeprazole increased the density of G-cells, whereas it decreased the density of D-cells. That effect was probably independent of hypergastrinaemia, since it could not be blocked by a simultaneous treatment with proglumide - a gastrin receptor blocker. It is concluded that the observed phenomenon is a direct result of a lower gastric acidity, as a consequence of omeprazole treatment.