Publication: Changes in Calprotectin (S100A8-A9) and Aldolase in the Saliva of Horses with Equine Gastric Ulcer Syndrome
Authors
Muñoz-Prieto, Alberto ; Contreras-Aguilar, María Dolores ; Cerón, José Joaquín ; Ayala de la Peña, Ignacio ; Martín-Cuervo, María ; David Eckersall, Peter ; Holm Henriksen, Ida-Marie ; Tecles, Fernando ; Hansen, Sanni
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Publisher
MDPI
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DOI
https://doi.org/10.3390/ani13081367
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info:eu-repo/semantics/article
Description
© 2023. The authors. This document is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/
This document is the published version of a published work that appeared in final form in Animals
To access the final work, see DOI: https://www.mdpi.com/2076-2615/13/8/1367
Abstract
Equine gastric ulcer syndrome (EGUS) is a highly prevalent disease that affects horses
worldwide. Within EGUS, two different forms have been described: equine squamous gastric disease
(ESGD) and equine glandular gastric disease (EGGD). The associated clinical signs cause detrimental
activity performance, reducing the quality of life of animals. Saliva can contain biomarkers for EGUS
that could be potentially used as a complementary tool for diagnosis. The objective of this work was
to evaluate the measurements of calprotectin (CALP) and aldolase in the saliva of horses as potential
biomarkers of EGUS. For this purpose, automated assays for the quantification of these two proteins
were analytically validated and applied for detecting EGUS in a total of 131 horses divided into
5 groups: healthy horses, ESGD, EGGD, combined ESGD and EGGD, and horses with other intestinal
pathologies. The assays showed good precision and accuracy in analytical validation, and they were
able to discriminate between horses with EGUS and healthy horses, especially in the case of CALP,
although they did not show significant differences between horses with EGUS and horses with other
diseases. In conclusion, salivary CALP and aldolase can be determined in the saliva of horses and
further studies are warranted to elucidate the potential of these analytes as biomarkers in EGUS.
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Citation
Animals 2023, 13, 1367
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