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Changes in Calprotectin (S100A8-A9) and Aldolase in the Saliva of Horses with Equine Gastric Ulcer Syndrome

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dc.contributor.authorMuñoz-Prieto, Alberto
dc.contributor.authorContreras-Aguilar, María Dolores
dc.contributor.authorCerón, José Joaquín
dc.contributor.authorAyala de la Peña, Ignacio
dc.contributor.authorMartín-Cuervo, María
dc.contributor.authorDavid Eckersall, Peter
dc.contributor.authorHolm Henriksen, Ida-Marie
dc.contributor.authorTecles, Fernando
dc.contributor.authorHansen, Sanni
dc.contributor.departmentMedicina y Cirugía Animal
dc.date.accessioned2024-09-10T08:57:36Z
dc.date.available2024-09-10T08:57:36Z
dc.date.created2023-01-16
dc.description© 2023. The authors. This document is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/ This document is the published version of a published work that appeared in final form in Animals To access the final work, see DOI: https://www.mdpi.com/2076-2615/13/8/1367es
dc.description.abstractEquine gastric ulcer syndrome (EGUS) is a highly prevalent disease that affects horses worldwide. Within EGUS, two different forms have been described: equine squamous gastric disease (ESGD) and equine glandular gastric disease (EGGD). The associated clinical signs cause detrimental activity performance, reducing the quality of life of animals. Saliva can contain biomarkers for EGUS that could be potentially used as a complementary tool for diagnosis. The objective of this work was to evaluate the measurements of calprotectin (CALP) and aldolase in the saliva of horses as potential biomarkers of EGUS. For this purpose, automated assays for the quantification of these two proteins were analytically validated and applied for detecting EGUS in a total of 131 horses divided into 5 groups: healthy horses, ESGD, EGGD, combined ESGD and EGGD, and horses with other intestinal pathologies. The assays showed good precision and accuracy in analytical validation, and they were able to discriminate between horses with EGUS and healthy horses, especially in the case of CALP, although they did not show significant differences between horses with EGUS and horses with other diseases. In conclusion, salivary CALP and aldolase can be determined in the saliva of horses and further studies are warranted to elucidate the potential of these analytes as biomarkers in EGUS.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.citationAnimals 2023, 13, 1367
dc.identifier.doihttps://doi.org/10.3390/ani13081367
dc.identifier.issnElectronic: 2076-2615
dc.identifier.urihttp://hdl.handle.net/10201/143807
dc.languageenges
dc.publisherMDPIes
dc.relationThis research was funded by the Seneca foundation of Murcia Regional Government, Spain, grant number 19894/GERM/15. A.M.-P. was funded by a post-doctoral fellowship “Ramón y Cajal” supported by the Ministerio de Ciencia e Innovación, Agencia Estatal de Investigación (AEI), Spain, and The European Next Generation Funds (NextgenerationEU) (RYC2021-033660-I).es
dc.relation.publisherversionhttps://www.mdpi.com/2076-2615/13/8/1367es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectSalivaes
dc.subjectEGUSes
dc.subjectESGDes
dc.subjectEGGDes
dc.subjectCalprotectines
dc.subjectAldolasees
dc.subjectBiomarkerses
dc.titleChanges in Calprotectin (S100A8-A9) and Aldolase in the Saliva of Horses with Equine Gastric Ulcer Syndromees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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