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Morphological studies of cytotoxic lesions in reversible endotoxic shock

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dc.contributor.authorGarcía, R.es
dc.contributor.authorDíaz-Laviada, l.es
dc.contributor.authorBosch, M.A.
dc.contributor.authorAbarca, S.
dc.contributor.authorPortolés, M.T.
dc.contributor.authorRisco, C.
dc.contributor.authorAinaga, M.J.
dc.contributor.authorPagani, R.
dc.contributor.authorMunicio, A.M.
dc.contributor.authorEscalona, J.
dc.date.accessioned2011-02-01T08:44:16Z
dc.date.available2011-02-01T08:44:16Z
dc.date.issued1990
dc.description.abstractReversible endotoxic shock was induced in adult rats by intravenous injection of E. coli Olll:B4 lipopolysaccharide (LPS) and the progression of metabolic and morphological alterations was evaluated. Serum samples and biopsies from adrenal gland, liver and lung were studied at different times after LPS injection. Histological changes in these tissues were observed after endotoxin administration, coinciding with both the acute-phase and the recovery-phase of shock (24-72h after LPS injection). Signs of tissue regeneration can be correlated with the regression of some serum parameters to their normal values. Al1 these results indicate that in this experimental model of endotoxic shock, a reversible status was established, which will allow further studies of the endotoxic pathophysiological mechanisms in vivo, avoiding the complexity of the non-reversible process.es
dc.formatapplication/pdfes
dc.format.extent6es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/18140
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectEndotoxic reversible shockes
dc.subjectExperimental modeles
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleMorphological studies of cytotoxic lesions in reversible endotoxic shockes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol. 5, nº 1 (1990)