Publication: Morphological studies of cytotoxic lesions in reversible endotoxic shock
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Date
1990
Authors
García, R. ; Díaz-Laviada, l. ; Bosch, M.A. ; Abarca, S. ; Portolés, M.T. ; Risco, C. ; Ainaga, M.J. ; Pagani, R. ; Municio, A.M. ; Escalona, J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Reversible endotoxic shock was induced in
adult rats by intravenous injection of E. coli Olll:B4
lipopolysaccharide (LPS) and the progression of
metabolic and morphological alterations was evaluated.
Serum samples and biopsies from adrenal gland, liver
and lung were studied at different times after LPS
injection.
Histological changes in these tissues were observed
after endotoxin administration, coinciding with both the
acute-phase and the recovery-phase of shock (24-72h
after LPS injection). Signs of tissue regeneration can be
correlated with the regression of some serum parameters
to their normal values.
Al1 these results indicate that in this experimental
model of endotoxic shock, a reversible status was
established, which will allow further studies of the
endotoxic pathophysiological mechanisms in vivo,
avoiding the complexity of the non-reversible process.
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