Publication: Mitochondrial support and local translation of mitochondrial proteins in synaptic plasticity and function
Authors
Liang, YongTian
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-345
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info:eu-repo/semantics/article
Description
Abstract
Complex neural and brain functions are
executed through structural and functional alterations of
synapses and neurons. Neuronal compartmentalization
requires neurons to allocate mitochondria and proteins in
a spatiotemporal manner to allow their plasticity,
function and homeostasis. Importantly, mitochondria are
known to interact with and modulate synaptic activities
through their ATP supply, calcium buffering and
signaling abilities. Over the years, mitochondrial support
and local translation (including mitochondrial proteins)
at neuronal sub-compartments and their synaptic
specializations have been considered critical for
maintaining synaptic plasticity and function. Recently,
evidence has shown that late endosomes can serve as
sites for local translation of mRNAs crucial for
mitochondrial integrity and mitochondrial compartments
can fuel plasticity-induced local translation. Indeed,
failed mitochondrial homeostasis and subsequent
synaptic dysfunction are often intricately linked in the
malfunction of the central nervous system in synaptic
aging and diseases. In this review, I will discuss the
critical role of local translation (including mitochondrial
proteins) in dendrites, axons and synapses on
neuronal/synaptic plasticity and function.
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Mitochondria , Synapse , Neuron , Local translation , Biogenesis , Synaptic plasticity , Memory , Aging , Desease
Citation
Histology and Histopathology Vol. 36, nº10 (2021)
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