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Mitochondrial support and local translation of mitochondrial proteins in synaptic plasticity and function

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dc.contributor.authorLiang, YongTian
dc.date.accessioned2023-01-26T11:08:26Z
dc.date.available2023-01-26T11:08:26Z
dc.date.issued2021
dc.description.abstractComplex neural and brain functions are executed through structural and functional alterations of synapses and neurons. Neuronal compartmentalization requires neurons to allocate mitochondria and proteins in a spatiotemporal manner to allow their plasticity, function and homeostasis. Importantly, mitochondria are known to interact with and modulate synaptic activities through their ATP supply, calcium buffering and signaling abilities. Over the years, mitochondrial support and local translation (including mitochondrial proteins) at neuronal sub-compartments and their synaptic specializations have been considered critical for maintaining synaptic plasticity and function. Recently, evidence has shown that late endosomes can serve as sites for local translation of mRNAs crucial for mitochondrial integrity and mitochondrial compartments can fuel plasticity-induced local translation. Indeed, failed mitochondrial homeostasis and subsequent synaptic dysfunction are often intricately linked in the malfunction of the central nervous system in synaptic aging and diseases. In this review, I will discuss the critical role of local translation (including mitochondrial proteins) in dendrites, axons and synapses on neuronal/synaptic plasticity and function.es
dc.formatapplication/pdfes
dc.format.extent13es
dc.identifier.citationHistology and Histopathology Vol. 36, nº10 (2021)
dc.identifier.doihttps://doi.org/10.14670/HH-18-345
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/127895
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMitochondriaes
dc.subjectSynapsees
dc.subjectNeurones
dc.subjectLocal translationes
dc.subjectBiogenesises
dc.subjectSynaptic plasticityes
dc.subjectMemoryes
dc.subjectAginges
dc.subjectDeseasees
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleMitochondrial support and local translation of mitochondrial proteins in synaptic plasticity and functiones
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.36,nº10 (2021)