Publication: Myeloid cell distribution and activity in multiple sclerosis
Authors
Moliné-Velázquez, Verónica ; Vila-del Sol, Virginia ; de Castro, Fernando ; Clemente, Diego
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
DOI: 10.14670/HH-11-699
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info:eu-repo/semantics/article
Description
Abstract
Multiple sclerosis (MS) is a demyelinating
disease in which an exacerbated immune response
provokes oligodendrocyte loss and demyelination, the
hallmarks of this neurological disease. The destruction
of myelin due to the uncontrolled activity of the
invading immune cells leads to the formation of MS
plaques. Among the different leukocytes that participate
in the immune response associated with MS, the role of
myeloid cells has been analyzed extensively (i.e.
macrophages, dendritic cells -DCs- and neutrophils).
Hence, in this review we will summarize what is known
about the distribution, expression and markers available
to study myeloid cells, and their histopathology, not only
in a standard animal model of MS (autoimmune
experimental encephalomyelitis -EAE) but also in MS
tissue. In this review, we will not only refer to mature
myeloid cells but also to the undifferentiated and almost
unexplored myeloid-derived suppressor cells (MDSCs).
The active role of MDSCs in the prompt resolution of an
immune episode is gaining importance, yet is still the
subject of some debate. Finally, the similarities and
differences between MS and EAE are discussed,
particularly in terms of myeloid cell phenotype, activity
and the markers used.
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Dendritic cells , MDSCs , Neutrophils , Macrophages , EAE , Demyelinaion , Remyelination , Myelin , Functionality
Citation
Histology and histopathology: Vol.31, nº4 (2016)
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Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/