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Myeloid cell distribution and activity in multiple sclerosis

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dc.contributor.authorMoliné-Velázquez, Verónica
dc.contributor.authorVila-del Sol, Virginia
dc.contributor.authorde Castro, Fernando
dc.contributor.authorClemente, Diego
dc.date.accessioned2021-06-17T09:37:07Z
dc.date.available2021-06-17T09:37:07Z
dc.date.issued2016
dc.description.abstractMultiple sclerosis (MS) is a demyelinating disease in which an exacerbated immune response provokes oligodendrocyte loss and demyelination, the hallmarks of this neurological disease. The destruction of myelin due to the uncontrolled activity of the invading immune cells leads to the formation of MS plaques. Among the different leukocytes that participate in the immune response associated with MS, the role of myeloid cells has been analyzed extensively (i.e. macrophages, dendritic cells -DCs- and neutrophils). Hence, in this review we will summarize what is known about the distribution, expression and markers available to study myeloid cells, and their histopathology, not only in a standard animal model of MS (autoimmune experimental encephalomyelitis -EAE) but also in MS tissue. In this review, we will not only refer to mature myeloid cells but also to the undifferentiated and almost unexplored myeloid-derived suppressor cells (MDSCs). The active role of MDSCs in the prompt resolution of an immune episode is gaining importance, yet is still the subject of some debate. Finally, the similarities and differences between MS and EAE are discussed, particularly in terms of myeloid cell phenotype, activity and the markers used.es
dc.formatapplication/pdfes
dc.format.extent14es
dc.identifier.citationHistology and histopathology: Vol.31, nº4 (2016)
dc.identifier.doiDOI: 10.14670/HH-11-699
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/109872
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectDendritic cellses
dc.subjectMDSCses
dc.subjectNeutrophilses
dc.subjectMacrophageses
dc.subjectEAEes
dc.subjectDemyelinaiones
dc.subjectRemyelinationes
dc.subjectMyelines
dc.subjectFunctionalityes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleMyeloid cell distribution and activity in multiple sclerosises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.31, nº4 (2016)