Publication:
The effects of cyclophosphamide on the gonadotrophic cells of the normal rat

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Date
1990
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Authors
Poblador, María S. ; Rojas, Carmen ; Raya, Antonio ; Casares, José A. ; Aparicio, J. ; Lancho Alonso, José Luis
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The effects of the administration of cyclophosphamide to male rats at doses of 400 mg/m2 for a period of 5 days and of 200 mg/m2 over two five-day cycles interrupted by a 21-day break reveal differences in the ultrastructural morphology of gonadotrophic cells between treated animals and normal controls. The ultrastructural data obtained coincide with the results obtained from the measurement of serum FSH and LH levels, indicating hypofunction. A significant fall was also recorded in blood testosterone levels. The two types of treatment did not give rise to morphological or functional differences.
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Gonadotrophic cells , Cyclophosphamide
Citation
URI
http://hdl.handle.net/10201/18153
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Collections
Histology and histopathology Vol. 5, nº 2 (1990)
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