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The lymphocyte-dendritic cell system

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dc.contributor.authorImai, Yutakaes
dc.contributor.authorYamakawa, Mitsunories
dc.contributor.authorKasajima, Takeshi
dc.date.accessioned2011-02-22T10:58:22Z
dc.date.available2011-02-22T10:58:22Z
dc.date.issued1998
dc.description.abstractAntigens provoke immune responses. The group of immunocompetent cells related directly to this response includes T and B cells, macrophages (MO) and dendritic cells (DCs). DCs acting as antigen-presenting cells have been recently recognized to be important in initiating the immune response. B cells and follicular dendritic cells (FDCs), the major immunocompetent cells in the B-cell dependent area, play an important role in humoral immunity, while T cells and interdigitating cells (IDCs), which are the major immunocompetent cells in the T-cell dependent (TD)-area, play an important role in cellular immunity. The B cell-IDC interaction in the TD-area is also essential for the B-cell response against TD-antigen. Consequently, the lymphocyte-DC interaction is essential in the response to antigenic stimulation and in inducing the potent effector cells. B cell-DC, T cell-DC and DC-B cell-T cell interactions are regulated in predetermined sites by complex and varied mechanisms. Much recent evidence demonstrates that DCs modulate lymphocyte biology in its broadest aspects, including generation, differen-tiation, proliferation, and activation. In this review, we outline recent studies on the generation, structure, and function of lymphatic tissues, propose the concept of the "Lymphocyte-Dendritic Cell System (LDS)", and finally describe the significance and functions of this system in health and disease.es
dc.formatapplication/pdfes
dc.format.extent42es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/19047
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectLymphoid folliclees
dc.subjectGerminal centrees
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleThe lymphocyte-dendritic cell systemes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.13, nº 2 (1998)