Publication: The lymphocyte-dendritic cell system
Authors
Imai, Yutaka ; Yamakawa, Mitsunori ; Kasajima, Takeshi
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Antigens provoke immune responses. The
group of immunocompetent cells related directly to this
response includes T and B cells, macrophages (MO) and
dendritic cells (DCs). DCs acting as antigen-presenting
cells have been recently recognized to be important in
initiating the immune response.
B cells and follicular dendritic cells (FDCs), the
major immunocompetent cells in the B-cell dependent
area, play an important role in humoral immunity, while
T cells and interdigitating cells (IDCs), which are the
major immunocompetent cells in the T-cell dependent
(TD)-area, play an important role in cellular immunity.
The B cell-IDC interaction in the TD-area is also
essential for the B-cell response against TD-antigen.
Consequently, the lymphocyte-DC interaction is
essential in the response to antigenic stimulation and in
inducing the potent effector cells. B cell-DC, T cell-DC
and DC-B cell-T cell interactions are regulated in predetermined
sites by complex and varied mechanisms.
Much recent evidence demonstrates that DCs modulate
lymphocyte biology in its broadest aspects, including
generation, differen-tiation, proliferation, and activation.
In this review, we outline recent studies on the
generation, structure, and function of lymphatic tissues,
propose the concept of the "Lymphocyte-Dendritic Cell
System (LDS)", and finally describe the significance and
functions of this system in health and disease.
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