Publication:
Expression of AGR2 in non small cell lung cancer

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dc.contributor.authorFritzsche, F.R.es
dc.contributor.authorDahl, E.es
dc.contributor.authorDankof, A.
dc.contributor.authorBurkhardt, M.
dc.contributor.authorPahl, S.
dc.contributor.authorPetersen, I.
dc.contributor.authorDietel, Manfred
dc.contributor.authorKristiansen, Gitte
dc.date.accessioned2012-05-21T12:10:19Z
dc.date.available2012-05-21T12:10:19Z
dc.date.issued2007
dc.description.abstractWe aimed to evaluate immunohistochemically the expression of the human Anterior Gradient-2 (AGR2), a gene which has recently been proposed as an oncogene for lung carcinoma development, in non small cell lung cancer and to correlate the findings to clinico-pathological data including patient survival. 95 cases of NSCLC were immunostained using a polyclonal AGR2 antibody and statistical analyses were applied to test for prognostic and diagnostic associations. AGR2 was expressed in 66.3% of cases, preferentially adenocarcinomas. There were no relevant associations with clinico-pathological paramaters. A prognostic value of AGR2 could not be demonstrated neither in multivariate nor in univariate analyses. Interestingly, this is the first study to demonstrate AGR2 expression in squamous cell carcinomas. Although a prognostic value of AGR2 seems unlikely further studies are warranted to investigate the biological role of AGR2 in NSCLC and its differential expression according to histology.es
dc.formatapplication/pdfes
dc.format.extent6es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/27610
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectLung canceres
dc.subjectImmunohistochemistryes
dc.subject.other616 - Patología. Medicina clínica. Oncologíaes
dc.titleExpression of AGR2 in non small cell lung canceres
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.22, nº 7 (2007)