Publication: Expression of AGR2 in non small cell lung cancer
Authors
Fritzsche, F.R. ; Dahl, E. ; Dankof, A. ; Burkhardt, M. ; Pahl, S. ; Petersen, I. ; Dietel, Manfred ; Kristiansen, Gitte
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
We aimed to evaluate immunohistochemically
the expression of the human Anterior
Gradient-2 (AGR2), a gene which has recently been
proposed as an oncogene for lung carcinoma
development, in non small cell lung cancer and to
correlate the findings to clinico-pathological data
including patient survival. 95 cases of NSCLC were
immunostained using a polyclonal AGR2 antibody and
statistical analyses were applied to test for prognostic
and diagnostic associations. AGR2 was expressed in
66.3% of cases, preferentially adenocarcinomas. There
were no relevant associations with clinico-pathological
paramaters. A prognostic value of AGR2 could not be
demonstrated neither in multivariate nor in univariate
analyses. Interestingly, this is the first study to
demonstrate AGR2 expression in squamous cell
carcinomas. Although a prognostic value of AGR2
seems unlikely further studies are warranted to
investigate the biological role of AGR2 in NSCLC and
its differential expression according to histology.
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