Publication: Effects of atorvastatin on progression - regression of renal injury in hyperlipidemic chickens
Loading...
Date
2008
Authors
Adánez Martínez, María de Gracia ; García Pérez, Bartolomé ; Sánchez-Polo, M.T. ; Montes, A. ; Ayala de la Peña, Ignacio ; Castells Mora, María Teresa
item.page.secondaryauthor
Biología Celular ; Medicina y Cirugía Animal
item.page.director
Martín Castillo, Antonia
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Complex interrelationships exist between
hyperlipidemia and the progression of renal injury. The
aim of this study was to evaluate the impact of high
plasma cholesterol and triglyceride levels on renal
structure and the effects of atorvastatin on progressionregression
of renal injury. One-hundred chickens were
divided into five groups: Group A: Standard diet (SD)
for 6 months; Group B: Hyperlipidemic diet (HD) for 6
months; Group C: HD for three months and SD during
the next 3 months; Group D: HD for 3 months and SD
during the next 3 months, when they received oral
atorvastatin (3 mg/kg/d); Group E: HD for the whole 6
months, and atorvastatin (3 mg/kg/d) during the last 3
months. Increased a-actine immunostaining was found
in glomeruli of groups B and C. An important decrease
of immunostaining was observed in glomeruli of
atorvastatin treated groups. Group D showed the lowest
value for presence of lipids, and significant differences
were found with respect to the rest of the groups. The
glomeruli of group B presented the highest damage
grades and those of group D showed the lowest grades
and presented significant differences from the rest of the
groups. The combination of atorvastatin therapy and
proper diet proved to be effective in promoting renal disease regression. However, the study of several
parameters indicates that neither only diet nor
atorvastatin in the progression group resulted completely
effective in decreasing the progression of the disease.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.