Publication: Sex differences in vanadium inhalation effects in non-ciliated bronchiolar cells
Authors
López Valdez, Nelly ; Rojas Lemus, Marcela ; Bizarro Nevares, Martha Patricia ; González Villalva, Adriana Elizabeth ; Ustarroz Cano, Martha Luz ; Casarrubias Tabarez, Brenda ; Guerrero Palomo, Gabriela ; Cervantes Valencia, María Eugenia ; Rivera Fernández, Norma ; Imelda Fortoul, Teresa
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
https://doi.org/10.14670/HH-18-566
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info:eu-repo/semantics/article
Description
Abstract
The non-ciliated bronchiolar cell (NCBC) is
responsible for the defense of the lung and responds to
negative stimuli such as exposure to toxic pro-oxidant
substances, which triggers the hyperproduction and
hypersecretion of mucins and CC16 protein. The
literature demonstrates that physiological and
pathological responses in the lung can be influenced by
the organism’s sex. The objective of this report was to
evaluate response differences to vanadium inhalation in
male and female CD-1 mice. Mice were exposed to
vanadium for four weeks. Hyperplasia of bronchiolar
epithelium, small inflammatory foci and sloughing of the
NCBC were observed, without changes between sexes
and throughout the exposure time. Mucosecretory
metaplasia was found in both males and females,
however it was more drastic in males. The expression of
CC16 increased in both sexes. This study demonstrated a
different susceptibility between male and female
mice exposed to vanadium inhalation regarding
mucosecretory metaplasia.
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Citation
Histology and Histopathology, Vol.38, nº7, (2023)
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