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Sex differences in vanadium inhalation effects in non-ciliated bronchiolar cells

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dc.contributor.authorLópez Valdez, Nelly
dc.contributor.authorRojas Lemus, Marcela
dc.contributor.authorBizarro Nevares, Martha Patricia
dc.contributor.authorGonzález Villalva, Adriana Elizabeth
dc.contributor.authorUstarroz Cano, Martha Luz
dc.contributor.authorCasarrubias Tabarez, Brenda
dc.contributor.authorGuerrero Palomo, Gabriela
dc.contributor.authorCervantes Valencia, María Eugenia
dc.contributor.authorRivera Fernández, Norma
dc.contributor.authorImelda Fortoul, Teresa
dc.date.accessioned2023-09-06T11:03:12Z
dc.date.available2023-09-06T11:03:12Z
dc.date.issued2023
dc.description.abstractThe non-ciliated bronchiolar cell (NCBC) is responsible for the defense of the lung and responds to negative stimuli such as exposure to toxic pro-oxidant substances, which triggers the hyperproduction and hypersecretion of mucins and CC16 protein. The literature demonstrates that physiological and pathological responses in the lung can be influenced by the organism’s sex. The objective of this report was to evaluate response differences to vanadium inhalation in male and female CD-1 mice. Mice were exposed to vanadium for four weeks. Hyperplasia of bronchiolar epithelium, small inflammatory foci and sloughing of the NCBC were observed, without changes between sexes and throughout the exposure time. Mucosecretory metaplasia was found in both males and females, however it was more drastic in males. The expression of CC16 increased in both sexes. This study demonstrated a different susceptibility between male and female mice exposed to vanadium inhalation regarding mucosecretory metaplasia.es
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dc.format.extent13es
dc.identifier.citationHistology and Histopathology, Vol.38, nº7, (2023)
dc.identifier.doihttps://doi.org/10.14670/HH-18-566
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/133687
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectVanadiumes
dc.subjectBronchiolees
dc.subjectMucosecretoryes
dc.subjectLunges
dc.subjectSex differenceses
dc.subjectNon-ciliated bronchiolar celles
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleSex differences in vanadium inhalation effects in non-ciliated bronchiolar cellses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.38, nº7 (2023)