Publication:
In vitro analysis of the cellular resistance to chemotherapeutic BCNU

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In vitro analysis of the cellular resistance to chemotherapeutic BCNU.pdf(2.52 MB)
Date
1992
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Authors
Caballero Navarro, A. ; Conde Guerri, B. ; Sinués Porta, E. ; Boada Apilluelo, E. ; Alcalá Arellano, A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Our asays in vitro show that BCNU inhibits cell proliferation in the Ca cell line experimental glioma and is dose-dependent, starting from 0.5 pg/ml of the drug with just an hour of exposure. For every tested concentration of BCNU it is shown that, from the fifth day after exposure, cellular resistance appeared. This resistance is justified by the capacity of cell DNA reparation. A study of the clonogenic capacity of the Ca cells exposed to BCNU also shows the appearance of cellular resistance for doses of 0.5 pglml and 1 pglml. Furthermore, the exposure of Ca cell cultures to BCNU at these levels produces a cellular evolution towards more differentiated morphological patterns.
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Chemotherapy , BCNU
Citation
URI
http://hdl.handle.net/10201/18314
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Histology and histopathology Vol. 7, nº 3 (1992)
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