Publication:
In vitro analysis of the cellular resistance to chemotherapeutic BCNU

Simple item page
dc.contributor.authorCaballero Navarro, A.es
dc.contributor.authorConde Guerri, B.es
dc.contributor.authorSinués Porta, E.
dc.contributor.authorBoada Apilluelo, E.
dc.contributor.authorAlcalá Arellano, A.
dc.date.accessioned2011-02-01T08:47:09Z
dc.date.available2011-02-01T08:47:09Z
dc.date.issued1992
dc.description.abstractOur asays in vitro show that BCNU inhibits cell proliferation in the Ca cell line experimental glioma and is dose-dependent, starting from 0.5 pg/ml of the drug with just an hour of exposure. For every tested concentration of BCNU it is shown that, from the fifth day after exposure, cellular resistance appeared. This resistance is justified by the capacity of cell DNA reparation. A study of the clonogenic capacity of the Ca cells exposed to BCNU also shows the appearance of cellular resistance for doses of 0.5 pglml and 1 pglml. Furthermore, the exposure of Ca cell cultures to BCNU at these levels produces a cellular evolution towards more differentiated morphological patterns.es
dc.formatapplication/pdfes
dc.format.extent5es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/18314
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectChemotherapyes
dc.subjectBCNUes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleIn vitro analysis of the cellular resistance to chemotherapeutic BCNUes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
In vitro analysis of the cellular resistance to chemotherapeutic BCNU.pdf
Size:
2.52 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Histology and histopathology Vol. 7, nº 3 (1992)