Browsing by Subject "BCNU"

Now showing 1 - 1 of 1
  • Thumbnail Image
    Publication
    Open Access
    In vitro analysis of the cellular resistance to chemotherapeutic BCNU
    (Murcia : F. Hernández, 1992) Caballero Navarro, A.; Conde Guerri, B.; Sinués Porta, E.; Boada Apilluelo, E.; Alcalá Arellano, A.
    Our asays in vitro show that BCNU inhibits cell proliferation in the Ca cell line experimental glioma and is dose-dependent, starting from 0.5 pg/ml of the drug with just an hour of exposure. For every tested concentration of BCNU it is shown that, from the fifth day after exposure, cellular resistance appeared. This resistance is justified by the capacity of cell DNA reparation. A study of the clonogenic capacity of the Ca cells exposed to BCNU also shows the appearance of cellular resistance for doses of 0.5 pglml and 1 pglml. Furthermore, the exposure of Ca cell cultures to BCNU at these levels produces a cellular evolution towards more differentiated morphological patterns.