Publication: Silk fibroin and graphene oxide composites promote human periodontal ligament stem cell spontaneous differentiation into osteo/cementoblast-like cells
Authors
Sánchez Vera, María del Mar ; Aznar-Cervantes, Salvador ; Jover, Eva ; García Bernal, David ; Oñate Sánchez, Ricardo Elías ; Hernández Romero, Diana ; Moraleda Jiménez, José María ; Collado-González, Mar ; Rodríguez Lozano, Francisco Javier ; Cenís, José L.
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Publisher
Mary Ann Liebert, Inc
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DOI
https://doi.org/10.1089/scd.2016.0028
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info:eu-repo/semantics/article
Description
Abstract
Graphene represents one of the most interesting additions to the tissue engineering toolbox. Novel graphenebased composites are required to improve the beneficial graphene properties in terms of tridimensional polymeric structure, conferring a higher mechanical strength and favoring the differentiation of human mesenchymal stem cells. Here, we have demonstrated in a wide range of composite combinations, the successful use of graphene and silk-fibroin constructs for future bioengineering applications in the field of clinical regenerative dentistry using human periodontal ligament stem cells. Our results provide exciting new data for the development of suitable scaffolds that allow good cell engrafting, preservation of cell viability and proliferation, promotion of spontaneous osteoblastic differentiation, and importantly, stimulation of a higher cementum physiological synthesis than using other different available biomaterials.
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Citation
Stem Cells and Development 2016, 25(22):1742-1754
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