Publication:
Preschool asthma symptoms in children born preterm: the relevance of lung function in infancy

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2020 Preschool asthma-Journal Clinical Medicine.pdf(948.25 KB)
Date
2020-10-18
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Authors
Sánchez-Solís de Querol, Manuel ; Parra Carrillo, María Soledad ; Mondéjar López, Pedro Enrique ; García Marcos, Patricia W. ; García-Marcos Álvarez, Luis Vicente
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Facultades de la UMU::Facultad de Medicina
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Publisher
MDPI
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Cirugía, Pediatría y Obstetricia y Ginecología
DOI
https://doi.org/10.3390/jcm9103345
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info:eu-repo/semantics/article
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Abstract
Background: The aim of the study is to assess whether lung function of infants born preterm predicts wheezing in pre-school age. Methods: A survey of the core wheezing questionnaire of the International Study on Asthma and Allergy in Children was administered to parents of preterm newborns, to whom lung function tests were performed at a corrected age of six months, and who, at the time of the survey, were between three and nine years of age. Results: Low values of all lung function parameters measured, except FVC, were predictors of wheezing at some time in life, (FEV0.5 OR: 0.62 (95%CI 0.39; 0.995); FEV0.5/FVC OR: 0.73 (0.54; 0.99)) FEF75 OR: 0.60 [0.37; 0.93]; FEF25-75 OR: 0.57 (0.37; 0.89)); and of wheezing in the past year (FEV0.5 OR: 0.36 (0.17; 0.76); FEV0.5/FVC OR: 0.59 (0.38; 0.93); FEF75 OR: 0.38 [0.19; 0.76]; FEF25-75 OR: 0.35 (0.17; 0.70). In addition, FEV0.5/FVC values lower than the lowest limit of normality, were predictive of hospital admissions due to wheezing (OR: 3.07; (1.02; 9.25)). Conclusions: Limited lung function in infancy is predictive of both future wheezing and hospitalization for a wheezing episode.
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Pre school asthma , Preterm newborn , Infant lung function
Citation
Sanchez-Solis M, Parra-Carrillo MS, Mondejar-Lopez P, Garcia-Marcos PW, Garcia-Marcos L. Preschool Asthma Symptoms in Children Born Preterm: The Relevance of Lung Function in Infancy. J Clin Med. 2020;9(10):3345
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http://hdl.handle.net/10201/194929
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